There refers to a place or a position.
We went there last night.
There are a lot of happy people at the store.
Their is the possessive form of they.
Their team is terrible.
Their service is excellent.
They’re is a contraction of they are.
They're coming over tomorrow.
They're going to be angry.
Its is the possessive form of it.
Its mission is to explore strange new worlds.
Its security is tight.
It’s is a contraction of it is.
It's cold today.
Your is the possessive form of you.
You’re is a contraction of you are.
You're running late.
You're doing it wrong.
Lose is a verb.
Lose a game
Lose your keys
While loose can be a verb, most of the time it’s an adjective.
A loose tooth
Loose fitting pants
The mistake most people make is using the word loose when they mean lose.